Labster Virtual Lab Experiments: Basic Genetics by Sarah Stauffer & Aaron Gardner & Wilko Duprez & Dewi Ayu Kencana Ungu & Philip Wismer

Author:Sarah Stauffer & Aaron Gardner & Wilko Duprez & Dewi Ayu Kencana Ungu & Philip Wismer
Language: eng
Format: epub
ISBN: 9783662579992
Publisher: Springer Berlin Heidelberg

Genome Scanning

Easily detectable DNA markers that are linked to an inherited trait can be identified using a technique known as genome scanning. The location of these markers indicates the chromosomal region where the gene responsible for the trait lies. This narrows the search down to a fraction of the genome.

The process of identifying gene markers that co‐segregate with an inherited trait is called linkage analysis.

Linkage Analysis

Linkage analysis identifies loci that co‐segregate in a pedigree, typically because they are closely located in the genome. It can be performed using two traits, or between DNA markers and a locus involved in an inherited disease.

Today, linkage analysis is typically performed to identify a candidate region and thereby focuses the search for a candidate gene to a limited chromosomal region.

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